Functionality of amidines and amidrazones

Nitrogen-bound diazeniumdiolated amidines.

In contrast to amidines bearing ionizable alpha-CH bonds, which react with nitric oxide (NO) to add diazeniumdiolate groups at their alpha-carbons, benzamidine forms an N-bound diazeniumdiolate that can be further derivatized at the other amidine nitrogen and/or the terminal oxygen to form caged NO compounds as potential NO prodrugs.

The estimation of aromatic amidines.

The inhibition of histaminase by amidines.

In normal Amount Total Error of recovery Method plasma added found (%) Spectrophotometric 079 0-5 1*28 -3-4 1*0 0.4 1*41 +2-5 -1*0 1.0 1*96 -4.0 -0-82 0-7 1-53 +1*4 -0*82 1*2 2*18 -1*7 Photoelectric 076 0 5 1F24 -4 0 -1-03 0-4 1*43 +1'2 -1-03 1.0 2*0 -3*0 -0'84 0 7 1*56 +2-8 -0*84 1*2 2*01 -2.5 Roe & Kuether (1943) -0-72 0 5 1-2 -4 0 -1.0 0.4 1*4 0.0 -1.0 1.0 1*96 -4*0 -0*88 0*7 1*6 +2-8 -0*88 ...

The determination of aromatic amidines in plasma and urine.

Certain aromatic amidines have been reported to be useful chemotherapeutic agents for the treatment of leishmaniasis, trypanosomiasis, and babesiasis (1). Pharmacological and clinical studies of these compounds have been handicapped by lack of suitable methods for the determination of aromatic amidines in plasma and urine. Recently Fuller (2) described a method which is based upon a reaction be...

postnatal studies of bats (pipistrellus kuhlii and miniopterus schreibersii) & histomorphology and histochemistry studies of organs and diseases of (neurergus microspilotus and n. kaiseri)

1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...